Research Notes -- New mouthwash formulation protects against tooth decayA research team at UNMC has developed a new mouthwash formulation that may provide long-term protection against tooth decay.
The team, led by Dong Wang, Ph.D., associate professor of pharmaceutical science in the UNMC College of Pharmacy, has developed a novel drug delivery system to carry antimicrobial agents directly to teeth. Their study was published in the November issue of Antimicrobial Agents and Chemotherapy and also was reported in the Nov. 22 issue of Science Daily.
|UNMC graduate student Fu Chen (left) with Dr. Dong Wang.|
"The beauty of this design is the simplicity," he said. "All you have to do is your routine oral hygiene procedure and then rinse with the formulation we have developed. It protects the teeth over a long period of time. The key is to have the antimicrobials stay where they are most needed -- the tooth surface."
Based upon the same principle, Dr. Wang's research group also explores using other drug delivery systems they have developed to improve the treatment of arthritis, cancer and several other inflammatory diseases.
A PCT (Patent Cooperation Treaty) application has been filed through UNeMed, the technology transfer arm of UNMC. Dr. Wang and his colleagues also seek funding to support a clinical trial and a cGMP (current Good Manufacturing Practice) facility to manufacture the formulation.