Search 1 -- Begin by defining the clinical question.
It's best to have a clear idea of the question you want to answer before you begin a MEDLINE search. Read over the clinical situation described below and then write down or mentally state the question you need to answer.
A liver transplant patient has been given cyclosporine to prevent transplant rejection and is beginning to show signs of renal failure. The patient's physicians have asked you to recommend an immunosuppressive regimen that has been proven to work in prevention of liver transplant rejection and is less likely to cause renal toxicity.