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About Mammalian Cell Adhesion Molecule (CAM) database
MCAM database is developed by Laboratory of Tumor Microenvironment at University of Nebraska Medical Center, Omaha, NE as part of a project to identify metastatic markers, which are adhesion molecules that help the cancer cells to home to a specific organ of metastasis. This is the first database known to be developed for cell adhesion molecules.
MCAM is an interactive web-based database serving the biology community to search sequence and details of CAMs including gene expression available from the mammalian genome. MCAM database is a database of cell adhesion molecules from mouse, human and rat. MCAM contains information about adhesion molecules from mouse, human and rat collected mainly from Gene Ontology (GO) and Gene (NCBI) database and cross referenced with SwissProt database. The information about the adhesion molecules collected from the database was used to curate data and information from various primary and secondary database sources. Primarily the database was created exclusively for mouse adhesion molecules and the data from the mouse were used as a reference to curate the orthologs available from the human and rat. This collected information were unified as a relational database using Microsoft Access and made available online.
Mammalian Cell Ahesion Molecule (MCAM) database, Version 3.0
- The version 3.0 has been updated from Local Mouse Cell Adhesion Molecule (LMCAM, version 2.0) Database and Mouse Cell Adhesion Molecule (MCAM, version 2.0).
- LMCAM is available in compact disc (CD).
- MCAM in http://molbio.unmc.edu/MCAM/MCAM.html.
Both LMCAM and MCAM are flat-file databases whereas MCAM is searchable database available online for users. MCAM has been updated with web links from different database sources as mentioned earlier.
Construction of MCAM, Version 3.0 database.
Statistics of MCAM, version 3.0 database
The functional terms from GO database and number of entries in the database from different source databases corresponding to the GO entries are shown.
| Functional Terms | GO | GenBank (FASTA) | UNIGENE | PIR |
| Calcium dependent cell adhesion | 12 | 6 | 8 | 25 |
| Calcium independent cell adhesion | 13 | 6 | 4 | 18 |
| Cell adhesion | 175 | 92 | 87 | 219 |
| Cell cell adhesion | 50 | 23 | 19 | 52 |
| Heterophilic cell adhesion | 8 | 5 | 5 | 12 |
| Homophilic cell adhesion | 54 | 39 | 39 | 2 |
| Positive regulation cell adhesion | 2 | 1 | 1 | 2 |
| Regulation cell adhesion | 20 | 8 | 8 | 25 |
The number of entries from different sources for mouse, human and rat has been listed.
| Sources | Mouse | Human | Rat |
| GenBank | 502 | 311 | 49 |
| GenPept | 430 | 147 | 135 |
| PIR | 472 | 154 | 67 |
| UniProt | 418 | 149 | 72 |
| UniGene | 610 | 184 | 80 |
The number of entries of cell adhesion molecules according to Superfamily Classification.
| Superfamily Classification |
| Superfamily | Number of Entries |
| Cadherin | 47 |
| Immunoglobulin Superfamily | 107 |
| Integrin | 21 |
| Selectin | 4 |
| Not Known | 78 |
This database was developed at Laboratory of Tumor Microenvironment,
University of Nebraska Medical Center, Omaha, NE, USA.
This database was developed by Anguraj Sadanandam and assisted by Supendar Nath Pal, Joe Ziskovisky, Prathibha Hegde and Eric Haas.
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